Aplasia Ras Homologous Member I Gene and Development of Glial Tumors
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چکیده
منابع مشابه
Aplasia Ras Homologous Member I Gene and Development of Glial Tumors
The ARHI (aplasia Ras homologue member I, also known as DIRAS3) gene shows 60.0% sequence homology to the Ras proto-oncogene and was the first mater-nally-imprinted tumor suppressor gene identified in the Ras family. It is constitutively expressed from the paternal allele in normal breast, ovary, heart, liver, pancreas, thyroid and brain tissues, and is lost or markedly down-regulated primarily...
متن کاملAplasia Ras homolog member I expression induces apoptosis in renal cancer cells via the β-catenin signaling pathway.
In numerous types of cancer, the Ras-associated tumor suppressor gene aplasia Ras homolog member I (ARHI), is downregulated. However, the function of ARHI in renal cancer remains to be elucidated. The present study investigated whether the suppressor gene ARHI influenced the growth of renal cancer cell lines and aimed to elucidate its mechanism of action, using the techniques of cell biology an...
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RhoA encodes a 21-kDa, 193 amino acids, small Rho GTPase; it displays potent oncogenic activity when overexpressed. RhoA structure: The N-terminal half of RhoA contains the majority of the amino acids involved in GTP binding and hydrolysis, together with the Switch 1 and 2 regions that change conformation between the GTP-bound and GDP-bound states. Several X-ray crystallographic structures of R...
متن کاملDetermination of CD117 Expression in Glial Tumors and Its Comparison between High Grade and Low Grade Tumors
Background and Objective: Gliomas are the most common primary brain tumors. Despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. CD117, the gene product of c-kit has been expressed in cells of glial tumors. Because gastrointestinal stromal tumors (GISTs) that express CD117 respond dramatically to treatment with tyrosine kinase inhibitors, ide...
متن کاملS-Phase Cell Cycle Arrest, Apoptosis, and Molecular Mechanisms of Aplasia Ras homolog Member I–Induced Human Ovarian Cancer SKOV3 Cell Lines
OBJECTIVE Aplasia Ras homolog member I (ARHI) is associated with human ovarian cancer (HOC) growth and proliferation; however, the mechanisms are unclear. The purpose of this study was to investigate ARHI effects in HOC SKOV3 cells. METHODS We transfected SKOV3 cells with PIRES2-EGFP-ARHI and measured growth inhibition rates, cell cycle distribution, apoptosis rates, and expression of P-STAT3...
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ژورنال
عنوان ژورنال: Balkan Journal of Medical Genetics
سال: 2011
ISSN: 1311-0160
DOI: 10.2478/v10034-011-0016-1